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Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developing new diagnostic and therapeutic approaches. Recent literature suggests that ageing may in...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Moro, Maria Luisa, Phillips, Andrew Stephen, Gaimster, Katie, Paul, Christian, Mudher, Amritpal, Nicoll, James A. R., Boche, Delphine
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753481/
https://ncbi.nlm.nih.gov/pubmed/29298722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0505-x
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