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Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion
Rapid digestion by proteases limits the application of peptides as therapeutics. One strategy to increase the proteolytic stability of peptides is the modification with fluorinated amino acids. This study presents a systematic investigation of the effects of fluorinated leucine and isoleucine deriva...
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| Vydáno v: | Beilstein J Org Chem |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Beilstein-Institut
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5753150/ https://ncbi.nlm.nih.gov/pubmed/29564015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.279 |
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