Isolation and Characterization of vΔI3 Confirm that Vaccinia Virus SSB Plays an Essential Role in Viral Replication

Vaccinia virus is unusual among DNA viruses in replicating exclusively in the cytoplasm of infected cells. The single-stranded DNA (ssDNA) binding protein (SSB) I3 is among the replication machinery encoded by the 195-kb genome, although direct genetic analysis of I3 has been lacking. Herein, we des...

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Bibliographic Details
Published in:J Virol
Main Authors: Greseth, Matthew D., Czarnecki, Maciej W., Bluma, Matthew S., Traktman, Paula
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752924/
https://ncbi.nlm.nih.gov/pubmed/29093092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01719-17
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