JQ1 induces DNA damage and apoptosis, and inhibits tumor growth in a patient-derived xenograft model of cholangiocarcinoma

Cholangiocarcinoma (CCA) is a fatal disease with a five-year survival of <30%. For a majority of patients chemotherapy is the only therapeutic option, and virtually all patients relapse. Gemcitabine is the frontline agent for treatment of CCA. Patients treated with gemcitabine monotherapy survive...

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書誌詳細
出版年:Mol Cancer Ther
主要な著者: Garcia, Patrick L., Miller, Aubrey L., Gamblin, Tracy L., Council, Leona N., Christein, John D., Arnoletti, J. Pablo, Heslin, Marty J., Reddy, Sushanth, Richardson, Joseph H., Cui, Xiangqin, van Waardenburg, Robert C.A.M., Bradner, James E., Yang, Eddy S., Yoon, Karina J.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752593/
https://ncbi.nlm.nih.gov/pubmed/29142067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0922
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