JQ1 induces DNA damage and apoptosis, and inhibits tumor growth in a patient-derived xenograft model of cholangiocarcinoma

Cholangiocarcinoma (CCA) is a fatal disease with a five-year survival of <30%. For a majority of patients chemotherapy is the only therapeutic option, and virtually all patients relapse. Gemcitabine is the frontline agent for treatment of CCA. Patients treated with gemcitabine monotherapy survive...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Garcia, Patrick L., Miller, Aubrey L., Gamblin, Tracy L., Council, Leona N., Christein, John D., Arnoletti, J. Pablo, Heslin, Marty J., Reddy, Sushanth, Richardson, Joseph H., Cui, Xiangqin, van Waardenburg, Robert C.A.M., Bradner, James E., Yang, Eddy S., Yoon, Karina J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752593/
https://ncbi.nlm.nih.gov/pubmed/29142067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0922
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