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miR-20a regulates Fas expression in osteosarcoma cells by modulating Fas promoter activity and can be therapeutically targeted to inhibit lung metastases

The metastatic potential of osteosarcoma cells is inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to escape Fas ligand-mediated apoptosis when they enter a Fas ligand-positive microenvironment such as the lung. We have previously demonstrated that...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Yang, Yuanzheng, Huang, Gangxiong, Zhou, Zhichao, Fewell, Jason G., Kleinerman, Eugenie S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752589/
https://ncbi.nlm.nih.gov/pubmed/29079708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0042
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