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miR-20a regulates Fas expression in osteosarcoma cells by modulating Fas promoter activity and can be therapeutically targeted to inhibit lung metastases
The metastatic potential of osteosarcoma cells is inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to escape Fas ligand-mediated apoptosis when they enter a Fas ligand-positive microenvironment such as the lung. We have previously demonstrated that...
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| Veröffentlicht in: | Mol Cancer Ther |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5752589/ https://ncbi.nlm.nih.gov/pubmed/29079708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0042 |
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