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miR-20a regulates Fas expression in osteosarcoma cells by modulating Fas promoter activity and can be therapeutically targeted to inhibit lung metastases

The metastatic potential of osteosarcoma cells is inversely correlated to cell surface Fas expression. Downregulation of Fas allows osteosarcoma cells to escape Fas ligand-mediated apoptosis when they enter a Fas ligand-positive microenvironment such as the lung. We have previously demonstrated that...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Yang, Yuanzheng, Huang, Gangxiong, Zhou, Zhichao, Fewell, Jason G., Kleinerman, Eugenie S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752589/
https://ncbi.nlm.nih.gov/pubmed/29079708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0042
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