Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells

Type 2 diabetes and obesity are negative prognostic factors in patients with breast cancer (BC). We found that sensitivity to tamoxifen was reduced by 2-fold by 25 mM glucose (High Glucose; HG) compared to 5.5 mM glucose (Low Glucose; LG) in MCF7 BC cells. Shifting from HG to LG ameliorated MCF7 cel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Ambrosio, Maria Rosaria, D’Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, Mosca, Giusy, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, Formisano, Pietro
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752499/
https://ncbi.nlm.nih.gov/pubmed/29312586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22552
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