Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells

Type 2 diabetes and obesity are negative prognostic factors in patients with breast cancer (BC). We found that sensitivity to tamoxifen was reduced by 2-fold by 25 mM glucose (High Glucose; HG) compared to 5.5 mM glucose (Low Glucose; LG) in MCF7 BC cells. Shifting from HG to LG ameliorated MCF7 cel...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Ambrosio, Maria Rosaria, D’Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, Mosca, Giusy, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, Formisano, Pietro
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752499/
https://ncbi.nlm.nih.gov/pubmed/29312586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22552
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