ICAM1(+) neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis

Neutrophils contribute to demyelinating autoimmune diseases, yet their phenotype and functions have been elusive to date. Here, we demonstrate that ICAM1 surface expression distinguishes extra- from intravascular neutrophils in the mouse CNS during experimental autoimmune encephalomyelitis (EAE). Tr...

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Publicat a:JCI Insight
Autors principals: Hawkins, Ryder F. Whittaker, Patenaude, Alexandre, Dumas, Aline, Jain, Rajiv, Tesfagiorgis, Yodit, Kerfoot, Steven, Matsui, Takeshi, Gunzer, Matthias, Poubelle, Patrice E., Larochelle, Catherine, Pelletier, Martin, Vallières, Luc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752297/
https://ncbi.nlm.nih.gov/pubmed/29212956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96882
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