B cell–derived IL-4 acts on podocytes to induce proteinuria and foot process effacement

The efficacy of B cell depletion therapies in diseases such as nephrotic syndrome and rheumatoid arthritis suggests a broader role in B cells in human disease than previously recognized. In some of these diseases, such as the minimal change disease subtype of nephrotic syndrome, pathogenic antibodie...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Kim, Alfred H.J., Chung, Jun-Jae, Akilesh, Shreeram, Koziell, Ania, Jain, Sanjay, Hodgin, Jeffrey B., Miller, Mark J., Stappenbeck, Thaddeus S., Miner, Jeffrey H., Shaw, Andrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752294/
https://ncbi.nlm.nih.gov/pubmed/29093269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.81836
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