T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy

In the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration (PCD), we discovered an unexpectedly high threshold for breaking CD8(+) cytotoxic T cell (CTL) tolerance to the PCD autoantigen, CDR2. While CDR2 expression was previously fo...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Blachère, Nathalie E., Orange, Dana E., Gantman, Emily C., Santomasso, Bianca D., Couture, Graeme C., Ramirez-Montagut, Teresa, Fak, John, O’Donovan, Kevin J., Ru, Zhong, Parveen, Salina, Frank, Mayu O., Moore, Michael J., Darnell, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752293/
https://ncbi.nlm.nih.gov/pubmed/29093272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96173
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