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The Onconeural Antigen cdr2 Is a Novel APC/C Target that Acts in Mitosis to Regulate C-Myc Target Genes in Mammalian Tumor Cells

Cdr2 is a tumor antigen expressed in a high percentage of breast and ovarian tumors and is the target of a naturally occurring tumor immune response in patients with paraneoplastic cerebellar degeneration, but little is known of its regulation or function in cancer cells. Here we find that cdr2 is c...

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Autors principals: O'Donovan, Kevin J., Diedler, Jennifer, Couture, Graeme C., Fak, John J., Darnell, Robert B.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850929/
https://ncbi.nlm.nih.gov/pubmed/20383333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010045
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