Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome

Sepsis-associated acute respiratory distress syndrome (ARDS) is characterized by neutrophilic inflammation and poor survival. Since neutrophil myeloperoxidase (MPO) activity leads to increased plasma 2-chlorofatty acid (2-ClFA) levels, we hypothesized that plasma concentrations of 2-ClFAs would asso...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Meyer, Nuala J., Reilly, John P., Feng, Rui, Christie, Jason D., Hazen, Stanley L., Albert, Carolyn J., Franke, Jacob D., Hartman, Celine L., McHowat, Jane, Ford, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752281/
https://ncbi.nlm.nih.gov/pubmed/29212955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96432
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