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Genomic Form of Rhodopsin DNA Nanoparticles Rescued Autosomal Dominant Retinitis Pigmentosa in the P23H Knock-in Mouse Model

Retinitis pigmentosa (RP) is a group of inherited retinal degenerative conditions and a leading cause of irreversible blindness. 25%–30% of RP cases are caused by inherited autosomal dominant (ad) mutations in the rhodopsin (Rho) protein of the retina, which impose a barrier for developing therapeut...

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Détails bibliographiques
Publié dans:Biomaterials
Auteurs principaux: Mitra, Rajendra Narayan, Zheng, Min, Weiss, Ellen R., Han, Zongchao
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752119/
https://ncbi.nlm.nih.gov/pubmed/29232624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.12.004
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