Substantia Nigra Volume Loss Before Basal Forebrain Degeneration in Early Parkinson Disease

OBJECTIVE: To test the hypothesis that degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in Parkinson disease (PD) using new multispectral structural magnetic resonance (MR) imaging tools to measure the volumes of the SNc and BF. DESIGN: M...

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Udgivet i:JAMA Neurol
Main Authors: Ziegler, David A., Wonderlick, Julien S., Ashourian, Paymon, Hansen, Leslie A., Young, Jeremy C., Murphy, Alex J., Koppuzha, Cecily K., Growdon, John H., Corkin, Suzanne
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751707/
https://ncbi.nlm.nih.gov/pubmed/23183921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2013.597
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