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Co-Cultured Continuously Bioluminescent Human Cells as Bioreporters for the Detection of Prodrug Therapeutic Impact Pre- and Post-Metabolism

Modern drug discovery workflows require assay systems capable of replicating the complex interactions of multiple tissue types, but that can still function under high throughput conditions. In this work, we evaluate the use of substrate-free autobioluminescence in human cell lines to support the per...

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Detalhes bibliográficos
Publicado no:Sensors (Basel)
Main Authors: Xu, Tingting, Conway, Michael, Frank, Ashley, Ripp, Steven, Sayler, Gary, Close, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751572/
https://ncbi.nlm.nih.gov/pubmed/29211045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/s17122827
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