Ethanol (E) Impairs Fetal Brain GSH Homeostasis by Inhibiting Excitatory Amino-Acid Carrier 1 (EAAC1)-Mediated Cysteine Transport

Central among the fetotoxic responses to in utero ethanol (E) exposure is redox-shift related glutathione (GSH) loss and apoptosis. Previously, we reported that despite an E-generated Nrf2 upregulation, fetal neurons still succumb. In this study, we investigate if the compromised GSH results from an...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Patel, Dhyanesh, Mahimainathan, Lenin, Narasimhan, Madhusudhanan, Rathinam, Marylatha, Henderson, George
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5751199/
https://ncbi.nlm.nih.gov/pubmed/29206135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18122596
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