In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice

siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response to injury. We proposed reducing constitutive gene and protein expression of L...

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Détails bibliographiques
Publié dans:J Drug Deliv
Auteurs principaux: Eadon, Michael T., Cheng, Ying-Hua, Hato, Takashi, Benson, Eric A., Ipe, Joseph, Collins, Kimberly S., De Luca, Thomas, El-Achkar, Tarek M., Bacallao, Robert L., Skaar, Todd C., Dagher, Pierre C.
Format: Artigo
Langue:Inglês
Publié: Hindawi 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750491/
https://ncbi.nlm.nih.gov/pubmed/29410918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4070793
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