Activation of the B-cell receptor successively activates NF-κB and STAT3 in chronic lymphocytic leukemia cells

In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. However, whereas IL-6 phosphorylates STAT3 with...

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Bibliografiset tiedot
Julkaisussa:Int J Cancer
Päätekijät: Rozovski, Uri, Harris, David M., Li, Ping, Liu, Zhiming, Jain, Preetesh, Veletic, Ivo, Ferrajoli, Alessandra, Burger, Jan, Thompson, Philip, Jain, Nitin, Wierda, William, Keating, Michael J., Estrov, Zeev
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749978/
https://ncbi.nlm.nih.gov/pubmed/28722170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30892
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