Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes

BACKGROUND: TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Olivan-Viguera, Aida, Garcia-Otin, Angel Luis, Lozano-Gerona, Javier, Abarca-Lachen, Edgar, Garcia-Malinis, Ana J., Hamilton, Kirk L., Gilaberte, Yolanda, Pueyo, Esther, Köhler, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749757/
https://ncbi.nlm.nih.gov/pubmed/29293584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190307
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