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Polycystin-1 interacts with TAZ to stimulate osteoblastogenesis and inhibit adipogenesis

The molecular mechanisms that transduce the osteoblast response to physical forces in the bone microenvironment are poorly understood. Here, we used genetic and pharmacological experiments to determine whether the polycystins PC1 and PC2 (encoded by Pkd1 and Pkd2) and the transcriptional coactivator...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Xiao, Zhousheng, Baudry, Jerome, Cao, Li, Huang, Jinsong, Chen, Hao, Yates, Charles R., Li, Wei, Dong, Brittany, Waters, Christopher M., Smith, Jeremy C., Quarles, L. Darryl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749530/
https://ncbi.nlm.nih.gov/pubmed/29202470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93725
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