SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth

SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role for SHARPIN in regulating melanoma growth. We observed that SHARPIN interacted with PRMT5, a type II protein arg...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tamiya, Hironari, Kim, Hyungsoo, Klymenko, Oleksiy, Kim, Heejung, Feng, Yongmei, Zhang, Tongwu, Han, Jee Yun, Murao, Ayako, Snipas, Scott J., Jilaveanu, Lucia, Brown, Kevin, Kluger, Harriet, Zhang, Hao, Iwai, Kazuhiro, Ronai, Ze’ev A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749505/
https://ncbi.nlm.nih.gov/pubmed/29227283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95410
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