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Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy
DNA double-strand breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways. Here, we showed that myeloid cell leukemia sequence 1 (Mcl-1) acts as a functional switch in selecting between HR and NHEJ pathways. Mcl-1 was cell cycle–regul...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749500/ https://ncbi.nlm.nih.gov/pubmed/29227281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92742 |
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