Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

DNA double-strand breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways. Here, we showed that myeloid cell leukemia sequence 1 (Mcl-1) acts as a functional switch in selecting between HR and NHEJ pathways. Mcl-1 was cell cycle–regul...

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Udgivet i:J Clin Invest
Main Authors: Chen, Guo, Magis, Andrew T., Xu, Ke, Park, Dongkyoo, Yu, David S., Owonikoko, Taofeek K., Sica, Gabriel L., Satola, Sarah W., Ramalingam, Suresh S., Curran, Walter J., Doetsch, Paul W., Deng, Xingming
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749500/
https://ncbi.nlm.nih.gov/pubmed/29227281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92742
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