Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones affect the differentiated phenotype of ordinarily quiescent adult glomerular podocytes. To do this, w...

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Udgivet i:J Clin Invest
Main Authors: Majumder, Syamantak, Thieme, Karina, Batchu, Sri N., Alghamdi, Tamadher A., Bowskill, Bridgit B., Kabir, M. Golam, Liu, Youan, Advani, Suzanne L., White, Kathryn E., Geldenhuys, Laurette, Tennankore, Karthik K., Poyah, Penelope, Siddiqi, Ferhan S., Advani, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749498/
https://ncbi.nlm.nih.gov/pubmed/29227285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95946
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