Saturation mutagenesis reveals manifold determinants of exon definition

To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene. All possible single and tandem dinucleotide substitutions were surveyed. Using high-throughput genetics, 5560 minige...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Res
Main Authors: Ke, Shengdong, Anquetil, Vincent, Zamalloa, Jorge Rojas, Maity, Alisha, Yang, Anthony, Arias, Mauricio A., Kalachikov, Sergey, Russo, James J., Ju, Jingyue, Chasin, Lawrence A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749175/
https://ncbi.nlm.nih.gov/pubmed/29242188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.219683.116
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