Saturation mutagenesis reveals manifold determinants of exon definition

To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene. All possible single and tandem dinucleotide substitutions were surveyed. Using high-throughput genetics, 5560 minige...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Ke, Shengdong, Anquetil, Vincent, Zamalloa, Jorge Rojas, Maity, Alisha, Yang, Anthony, Arias, Mauricio A., Kalachikov, Sergey, Russo, James J., Ju, Jingyue, Chasin, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749175/
https://ncbi.nlm.nih.gov/pubmed/29242188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.219683.116
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