Saturation mutagenesis reveals manifold determinants of exon definition

To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene. All possible single and tandem dinucleotide substitutions were surveyed. Using high-throughput genetics, 5560 minige...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Genome Res
Autores principales: Ke, Shengdong, Anquetil, Vincent, Zamalloa, Jorge Rojas, Maity, Alisha, Yang, Anthony, Arias, Mauricio A., Kalachikov, Sergey, Russo, James J., Ju, Jingyue, Chasin, Lawrence A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749175/
https://ncbi.nlm.nih.gov/pubmed/29242188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.219683.116
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares