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Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect
BACKGROUND: To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe a method, applicable to a broad range of association study designs, that can simulate autosome-wide single-nucleotide polymorphism data with realistic...
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| Publicado no: | BMC Bioinformatics |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749028/ https://ncbi.nlm.nih.gov/pubmed/29291710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-2004-2 |
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