P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

BACKGROUND: Toxoplasma gondii can invade and replicate in all nucleated cells in a wide range of host species, and infection induces IL-1β production. IL-1β plays central roles in the stimulation of the innate immune system and inflammation. However, little is known of the innate immune responses in...

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Bibliographische Detailangaben
Veröffentlicht in:Parasit Vectors
Hauptverfasser: Quan, Juan-Hua, Huang, Rui, Wang, Zhuang, Huang, Shuai, Choi, In-Wook, Zhou, Yu, Lee, Young-Ha, Chu, Jia-Qi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748956/
https://ncbi.nlm.nih.gov/pubmed/29291748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13071-017-2573-y
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