Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils

There is compelling evidence for the role of the leucine-rich repeat kinase 2 (LRRK2) and in particular its kinase function in Parkinson's disease. Orally bioavailable, brain penetrant and potent LRRK2 kinase inhibitors are in the later stages of clinical development. Here, we describe a facile...

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Библиографические подробности
Опубликовано в: :Biochem J
Главные авторы: Fan, Ying, Howden, Andrew J.M., Sarhan, Adil R., Lis, Pawel, Ito, Genta, Martinez, Terina N., Brockmann, Kathrin, Gasser, Thomas, Alessi, Dario R., Sammler, Esther M.
Формат: Artigo
Язык:Inglês
Опубликовано: Portland Press Ltd. 2018
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748842/
https://ncbi.nlm.nih.gov/pubmed/29127255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170803
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