Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics

Orexins/hypocretins are neuropeptides formed by proteolytic cleavage of a precursor peptide, which are produced by neurons found in the lateral hypothalamus. The G protein-coupled receptors (GPCRs) for these ligands, the OX(1) and OX(2) orexin receptors, are more widely expressed throughout the cent...

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Bibliografiske detaljer
Udgivet i:Pharmaceuticals (Basel)
Main Authors: Thompson, Miles D., Sakurai, Takeshi, Rainero, Innocenzo, Maj, Mary C., Kukkonen, Jyrki P.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748636/
https://ncbi.nlm.nih.gov/pubmed/28991183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph10040079
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