PSMA-targeted polyinosine/polycytosine vector induces prostate tumor regression and invokes an antitumor immune response in mice

There is an urgent need for an effective treatment for metastatic prostate cancer (PC). Prostate tumors invariably overexpress prostate surface membrane antigen (PSMA). We designed a nonviral vector, PEI-PEG-DUPA (PPD), comprising polyethylenimine–polyethyleneglycol (PEI–PEG) tethered to the PSMA li...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Langut, Yael, Talhami, Alaa, Mamidi, Samarasimhareddy, Shir, Alexei, Zigler, Maya, Joubran, Salim, Sagalov, Anna, Flashner-Abramson, Efrat, Edinger, Nufar, Klein, Shoshana, Levitzki, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748205/
https://ncbi.nlm.nih.gov/pubmed/29229829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714587115
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