PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses

The treatment of metastatic androgen-resistant prostate cancer remains a challenge. We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Langut, Yael, Edinger, Nufar, Flashner-Abramson, Efrat, Melamed-Book, Naomi, Lebendiker, Mario, Levi-Kalisman, Yael, Klein, Shoshana, Levitzki, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421826/
https://ncbi.nlm.nih.gov/pubmed/28445962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15733
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