Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality

Bacterial natural products remain an important source of new medicines. DNA sequencing has revealed that a majority of natural product biosynthetic gene clusters (BGCs) maintained in bacterial genomes have yet to be linked to the small molecules whose biosynthesis they encode. Efforts to discover th...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Amos, Gregory C. A., Awakawa, Takayoshi, Tuttle, Robert N., Letzel, Anne-Catrin, Kim, Min Cheol, Kudo, Yuta, Fenical, William, S. Moore, Bradley, Jensen, Paul R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748202/
https://ncbi.nlm.nih.gov/pubmed/29229817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714381115
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