ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4(+) T cell pathogenicity during CNS inflammation

Although reactivation and accumulation of autoreactive CD4(+) T cells within the CNS are considered to play a key role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), the mechanisms of how these cells recognize their target organ...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Keller, Christian W., Sina, Christina, Kotur, Monika B., Ramelli, Giulia, Mundt, Sarah, Quast, Isaak, Ligeon, Laure-Anne, Weber, Patrick, Becher, Burkhard, Münz, Christian, Lünemann, Jan D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748192/
https://ncbi.nlm.nih.gov/pubmed/29233943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1713664114
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