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X-ray crystallography and NMR show that 5-formylcytosine does not change the global structure of DNA
The mechanism by which 5-formylcytosine (fC) is recognised by enzymes involved in epigenetic modification and reading of DNA is not known, and recently an unusual DNA structure (F-DNA) was proposed as the basis for enzyme recognition of clusters of fC. We used NMR and X-ray crystallography to compar...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5747368/ https://ncbi.nlm.nih.gov/pubmed/28504696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3411 |
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