Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

BACKGROUND: Exposure to ambient ozone (O(3)) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O(3) to trigger asthma exacerbations are still unclear. METHODS: An ovalbumin (OVA)-established asthmatic mouse mode...

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Udgivet i:Respir Res
Main Authors: Bao, Aihua, Yang, Hong, Ji, Jie, Chen, Yuqin, Bao, Wuping, Li, Feng, Zhang, Min, Zhou, Xin, Li, Qiang, Ben, Suqin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747109/
https://ncbi.nlm.nih.gov/pubmed/29284473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0697-4
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