Strategy to detect pre-existing immunity to AAV gene therapy

Gene therapy may offer a new treatment option, particularly for patients with severe hemophilia, based on recent research. However, individuals with pre-existing immunity to adeno-associated viruses (AAVs) may be less likely to benefit from AAV vector-based therapies. To study pre-existing AAV5 immu...

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Bibliografische gegevens
Gepubliceerd in:Gene Ther
Hoofdauteurs: Falese, L, Sandza, K, Yates, B, Triffault, S, Gangar, S, Long, B, Tsuruda, L, Carter, B, Vettermann, C, Zoog, S J, Fong, S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746592/
https://ncbi.nlm.nih.gov/pubmed/29106404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.95
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