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Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning

Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target genes. Activation of Shh signalling prevents...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Open Biol
Prif Awduron: Kawano, Rie, Ohta, Kunimasa, Lupo, Giuseppe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746549/
https://ncbi.nlm.nih.gov/pubmed/29263249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.170225
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