The Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Pro-Inflammatory and Pro-Resolving Lipid Mediators

OBJECTIVE: Human genetic variants near the fatty acid desaturase (FADS) gene cluster (FADS1–2–3) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes, and coronary artery disease. However, mechanisms underlying these genetic associations are unclea...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Gromovsky, Anthony D., Schugar, Rebecca C., Brown, Amanda L., Helsley, Robert N., Burrows, Amy C., Ferguson, Daniel, Zhang, Renliang, Sansbury, Brian E., Lee, Richard G., Morton, Richard E., Allende, Daniela S., Parks, John S., Spite, Matthew, Brown, J. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746431/
https://ncbi.nlm.nih.gov/pubmed/29074585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309660
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