The Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Pro-Inflammatory and Pro-Resolving Lipid Mediators

OBJECTIVE: Human genetic variants near the fatty acid desaturase (FADS) gene cluster (FADS1–2–3) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes, and coronary artery disease. However, mechanisms underlying these genetic associations are unclea...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Gromovsky, Anthony D., Schugar, Rebecca C., Brown, Amanda L., Helsley, Robert N., Burrows, Amy C., Ferguson, Daniel, Zhang, Renliang, Sansbury, Brian E., Lee, Richard G., Morton, Richard E., Allende, Daniela S., Parks, John S., Spite, Matthew, Brown, J. Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746431/
https://ncbi.nlm.nih.gov/pubmed/29074585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309660
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