Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system

Because androgen function is regulated by its receptors, androgen-androgen receptor signaling is crucial for regulating spermatogenesis. Androgen is mainly testosterone secreted by testis. Based on the results of early studies in goats, the administration of melatonin over an extended period of time...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Deng, Shou-Long, Zhang, Yan, Yu, Kun, Wang, Xiu-Xia, Chen, Su-Ren, Han, De-Ping, Cheng, C. Yan, Lian, Zheng-Xing, Liu, Yi-Xun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746406/
https://ncbi.nlm.nih.gov/pubmed/29299171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22855
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