Pharmacokinetic and safety profile of tofacitinib in children with polyarticular course juvenile idiopathic arthritis: results of a phase 1, open-label, multicenter study

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective of this study was to characterize the PK, safety, and taste acceptability of tofacitinib in patients with JIA. METHODS: This Phase 1, open-label,...

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Detalhes bibliográficos
Publicado no:Pediatr Rheumatol Online J
Main Authors: Ruperto, Nicolino, Brunner, Hermine I., Zuber, Zbigniew, Tzaribachev, Nikolay, Kingsbury, Daniel J., Foeldvari, Ivan, Horneff, Gerd, Smolewska, Elzbieta, Vehe, Richard K., Hazra, Anasuya, Wang, Rong, Mebus, Charles A., Alvey, Christine, Lamba, Manisha, Krishnaswami, Sriram, Stock, Thomas C., Wang, Min, Suehiro, Ricardo, Martini, Alberto, Lovell, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745974/
https://ncbi.nlm.nih.gov/pubmed/29282090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12969-017-0212-y
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