Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS

OBJECTIVE: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. METHOD: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or withou...

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Detalhes bibliográficos
Publicado no:Biochem Res Int
Main Authors: Zheng, Xiang, Wen, Jian, Liu, Teng-hui, Ou-yang, Qiu-Geng, Cai, Jian-ping, Zhou, Hong-yu
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745716/
https://ncbi.nlm.nih.gov/pubmed/29387488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/6510232
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