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The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone

The neurogenic locus notch homolog protein (Notch)-2 receptor is a determinant of B-cell allocation, and gain-of-NOTCH2–function mutations are associated with Hajdu–Cheney syndrome (HCS), a disease presenting with osteoporosis and acro-osteolysis. We generated a mouse model reproducing the HCS mutat...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Yu, Jungeun, Zanotti, Stefano, Walia, Bhavita, Jellison, Evan, Sanjay, Archana, Canalis, Ernesto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745525/
https://ncbi.nlm.nih.gov/pubmed/29037852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2017.09.010
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