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PYR-41, A UBIQUITIN-ACTIVATING ENZYME E1 INHIBITOR, ATTENUATES LUNG INJURY IN SEPSIS

During sepsis, systemic inflammation is observed and is associated with multiple organ failure. Activation of NF-κB is crucial for inducing inflammation, which is controlled by degradation of IκB. The ubiquitination proteasome pathway is responsible for the regulation of protein turnover. In this st...

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Detalhes bibliográficos
Publicado no:Shock
Principais autores: Matsuo, Shingo, Sharma, Archna, Wang, Ping, Yang, Weng-Lang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745315/
https://ncbi.nlm.nih.gov/pubmed/28661933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000931
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