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Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm

The noncoding genome is pervasively transcribed. Noncoding RNAs (ncRNAs) generated from enhancers have been proposed as a general facet of enhancer function and some have been shown to be required for enhancer activity. Here we examine the transcription-factor-(TF)-dependence of ncRNA expression to...

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Veröffentlicht in:eLife
Hauptverfasser: Yang, Xinan H, Nadadur, Rangarajan D, Hilvering, Catharina RE, Bianchi, Valerio, Werner, Michael, Mazurek, Stefan R, Gadek, Margaret, Shen, Kaitlyn M, Goldman, Joseph Aaron, Tyan, Leonid, Bekeny, Jenna, Hall, Johnathon M, Lee, Nutishia, Perez-Cervantes, Carlos, Burnicka-Turek, Ozanna, Poss, Kenneth D, Weber, Christopher R, de Laat, Wouter, Ruthenburg, Alexander J, Moskowitz, Ivan P
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745077/
https://ncbi.nlm.nih.gov/pubmed/29280435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31683
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