Inhibitory activity of pentacyano(isoniazid)ferrate(II), IQG-607, against promastigotes and amastigotes forms of Leishmania braziliensis

M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M. tuberculosis, a key component in the FASII system. Here, we aim...

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Vydáno v:PLoS One
Hlavní autoři: Amorim, Camila F., Galina, Luiza, Carvalho, Natália B., Sperotto, Nathalia D. M., Pissinate, Kenia, Machado, Pablo, Campos, Maria M., Basso, Luiz A., Rodrigues-Junior, Valnês S., Carvalho, Edgar M., Santos, Diógenes Santiago
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745003/
https://ncbi.nlm.nih.gov/pubmed/29281707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190294
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