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Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: A mechanistic model
Experimentally derived apparent permeabilities, P(app), through cell monolayers such as Caco-2 and MDCK are considered to be an in-vitro gold standard for assessing the uptake efficiency of drugs. Here, we present a mechanistic model that describes ‘passive’ P(app) values (i.e., neglecting active tr...
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| 發表在: | PLoS One |
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| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5744993/ https://ncbi.nlm.nih.gov/pubmed/29281711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190319 |
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