Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease

Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of the prion protein (PrP(Sc))] in the central nervous system (CNS). Some epidemiological studies have associated sCJD risk wi...

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Publicado no:Sci Transl Med
Main Authors: Orrú, Christina D., Yuan, Jue, Appleby, Brian S., Li, Baiya, Li, Yu, Winner, Dane, Wang, Zerui, Zhan, Yi-An, Rodgers, Mark, Rarick, Jason, Wyza, Robert E., Joshi, Tripti, Wang, Gong-Xian, Cohen, Mark L., Zhang, Shulin, Groveman, Bradley R., Petersen, Robert B., Ironside, James W., Quiñones-Mateu, Miguel E., Safar, Jiri G., Kong, Qingzhong, Caughey, Byron, Zou, Wen-Quan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744860/
https://ncbi.nlm.nih.gov/pubmed/29167394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aam7785
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