SUSTAINED INTRA-CARTILAGE DELIVERY OF LOW DOSE DEXAMETHASONE USING A CATIONIC CARRIER FOR TREATMENT OF POST TRAUMATIC OSTEOARTHRITIS

Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were uti...

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Veröffentlicht in:Eur Cell Mater
Hauptverfasser: Bajpayee, Ambika G., De la Vega, Rodolfo E., Scheu, Maximiliano, Varady, Nathan H., Yannatos, Isabel A., Brown, Lennart A., Krishnan, Yamini, Fitzsimons, Tomas J., Bhattacharya, Paulomi, Frank, Eliot H., Grodzinsky, Alan J., Porter, Ryan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744663/
https://ncbi.nlm.nih.gov/pubmed/29205258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22203/eCM.v034a21
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