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High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-25 and Syntaxin. These mutations could account f...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Carle, Stefan, Pirazzini, Marco, Rossetto, Ornella, Barth, Holger, Montecucco, Cesare
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744124/
https://ncbi.nlm.nih.gov/pubmed/29257047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9120404
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