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High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans

The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-25 and Syntaxin. These mutations could account f...

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Podrobná bibliografie
Vydáno v:Toxins (Basel)
Hlavní autoři: Carle, Stefan, Pirazzini, Marco, Rossetto, Ornella, Barth, Holger, Montecucco, Cesare
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744124/
https://ncbi.nlm.nih.gov/pubmed/29257047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9120404
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